National Aeronautics and Space Administration

Glenn Research Center

BioInVision, Inc.

A cryo-imaged section of a mouse.
Credit: Case Western Reserve University

January 31, 2014

Company Info:

BioInVision, Inc., located in Cleveland, Ohio, is developing a 3-D microscopic cryo-imaging system, which can detect and spatially map nearly every stem cell in a mouse or organ to help solve Biotechnology problems in cancer and stem research. The applications and algorithms for the pre-clinical market developed to date have won several competitive awards from National Institute of Health and other agencies.

“We will be able to augment our line of existing products with additional, more affordable, bench top version and grow our revenue, as well as our employment.  Our customers wanted a smaller more compact system . . . we struggled with the optics system . . . we were looking for a facility to test the optics . . . NASA was a huge advantage to us.  After an interactive process . . . We were able to come up with a very optimized set of optics that we could then piece together that resulted in an assembled instrument.”
-Debashish Roy, President, BioInVision


NASA Glenn Research Center partnered with Manufacturing Advocacy and Growth Network (MAGNET), the City of Cleveland and Cuyahoga County, as a part of the White House’s Strong Cities, Strong Communities Initiative – the Adopt-a-City program, to award BioInVision an opportunity to work with NASA subject matter experts for up to 40 hours to solve specific product questions.


BioInVision’s challenge to NASA was to reduce overall system size and cost by eliminating complex 2D scanning. The requirement was to create a lower cost, non-scanning, system that produces simultaneous high resolution and wide field of view, that still supports fluorescence capability. Working with NASA Glenn’s imaging specialists, an image capture device was recommended to the team at BioInVision. After some joint project planning and testing, NASA also completed a test of the system to help verify the results.


Working with NASA Glenn’s electro-optical specialists, an image capture device system was recommended to the team. This effort included several iterations to determine the most commercially viable solution for BioInVisions Invasion’s imaging system. In order to validate the BioInVision imaging system, NASA completed tests to verify that the system meets specific performance requirements.


NASA helped BioInVision save a lot of time and money by putting together a low cost imaging system that met BioInVisions requirements. After some continued testing, it is the expectation that BioInVision will grow revenue as well as employment as a result of the work that was accomplished by NASA and BioInVision.